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Objective: We aimed to assess the role of FDG PET/CT in detection of tumor recurrence in breast cancer patients with raised serum tumor markers and/or negative or equivocal abnormalities detected in other diagnostic imaging modalities. Patients and Methods: This prospective study was done on 100 previously diagnosed and treated breast cancer patients, All of patients referred for FDG-PET/CT scans in view of increased their serum tumour markers and/or equivocal abnormalities in other diagnostic imaging modalities. Clinical follow-up, tumour markers, conventional imaging modalities and FDG-PET/CT whole body scan was performed for each patient. Results: PET/CT detected recurrence and/or metastases in 63 out of 100 patients, including 23 loco-regional recurrence, 11 solitary organ involvement, 29 multiple organ involvement, whereas, other radiological modalities detected lesions in only 51 patients, those were 12 loco-regional recurrence, 24 solitary organ involvement, 15 multiple organ involvement. Fifty patients out of 59 with true positive PET/CT had raised tumor markers,either carcino-embryonic antigen (CEA) or CA 15-3 , while 2 patients with raised tumor markers showed negative PET/CT study(FN). Forty eight patients had normal serum level of tumor markers, nine of them showed positive PET/CT study. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT were 96.7, 89.7, 93.7,94.2 and 94% respectively. These parameters were 72.1, 82, 86.3, 65.3 and 76% for conventional imaging modalities.Conclusion: PET-CT is a powerful diagnostic method in the restaging of breast cancer and detection of metastases in patients with raised serum tumor markers and/or negative or equivocal radiologic imaging modalities, however conventional imaging modalities with multiphase CT or MRI are more sensitive in detection of early small lesions in liver and lung.

Role of 18F- FDG-PET/CT in Restaging of Breast Cancer Patients with High Tumour Markers and Equivocal Radiological Imaging