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Objectives : To test if Corticosleroids (mcthylprcdniosolonc) reduces and prevents OHSS in women undergoing IVF-ICSI cycles. Design : Prospective, randomized study. Setting : Shalby hospital for women and Elmadina IVF-ICSI center. Patients : 67 women undergoing IVF-ICSI from May 2006 to April 2007. Intervention : Corticostcroid (Mcthylprcdinsolonc), was given at the day of oocyle recovery till the day of pregnancy test then the dose was tapered. Main Outcome Measure(s) : Occurrence of OHSS and pregnancy. Results : A significantly lower proportion of methylprcdnisolone recipients than untreated participants developed OHSS (20% vs. 43%). Treatment recipients had more oocytcs retrieved and moc embryos fertilized than did untreated participants. Conclusions : Given the corticostcroid (methylprcdnisolone) is a well established and safe medication. This study provides evidence that the use of methylprcdnisolone in the prevention of OHSS in women undergoing assisted reproduction, is successful and without affection of the pregnancy rate.

ADMINISTRATION OF CORTICOSTEROIDS TO PREVENT SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN PATIENTS UNDERGOING GnRH AGONIST DOWN REGULATED ICSI CYCLES