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The relationship between cytokines and human reproduction has been the subject of a variety of studies because of theirinvolvement in reproductive physiology and gonadal function.Objective: To assess the clinical value of measurement of interleukin-6 (IL-6) in seminal plasma of infertile men and asa marker of male accessory gland infection.Patients and Methods: Ninety men were subjected to this study (75 infertile & 15 fertile). All studied individuals weresubjected to; medical history, physical examination, Doppler ultrasonography on scrotum, semen analysis, detection ofantisperrn antibodies (ASAbs), serum FSH and LH, measurement of IL-6 concentration in seminal plasma (SP). Thestudied population were classified into 6 groups; I (fertile), 2 (azoospermia), 3 (immuno-infertile), 4 (varicocele), 5(oligo-astheno-terato-zoospermia, OAT) and 6 (OAT +infection).Results: Showed that IL-6 was expressed in seminal plasma of all studied groups and its median concentration was 29Pg/rnl. IL-6 concentration showed a high statistical significant difference between all studied groups (p 0.05). However, pH value in group 3 and 6 showed significant difference when compared with that of fertile group (p 0.05). High IL-6 value was noticed in cases associated with ASAbs.In Conclusion : This study revealed that the IL-6 most probably has a role in male infertility cases which areassociated with infection, immuno-infertile cases and with varicocele. Moreover, the simultaneous determination ofIL-6 in SP may provide a sensitive and useful marker of silent infection I inflammation of the male genital tract.

INTERLEUKIN-6 EXPRESSION IN SEMINAL PLASMA OF INFERTILE MALES