English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Monosodium glutamate is a well-known food flavor additives that is widely used all over the world but its chronic intake leads to many reported side effects. Objectives : The goal of this study was to evaluate the prophylactic role of chitosan and curcumine extract, as a well-known antioxidant, against the submandibular salivary gland (SMG) damage induced by chronic intake of monosodium glutamate (MSG). Material and methods: 36 adult male Albino rats were randomly divided into 4 groups; Group 1 (control) group, group 2 (MSG group): rats received a daily dose of MSG only by oral gavage, group 3 ( MSG + Chitosan treated group): rats received a daily dose of MSG + chitosan and finally group 4 ( MSG + curcumin treated group): rats received a daily dose of MSG + curcumin. After 6 weeks, the submandibular salivary glands were excised and processed for histological and caspase 3 immunohistochemical examination. Results: histological examination by H&E stain of group 3 and 4 revealed improvement of secretory portion architecture in addition to decreased vaculation and pleomorphism than group 2. There were a high statistical significant difference of caspase 3 immuno-expression between the treated chitosan and curcumin groups (group3 and 4) and MSG group (group 2) as p values were 0.005 and 0.017 respectively. Conclusion: administration of chitosan or curcumin has a protective effect on SMG toxicity induced by chronic intake of MSG.

Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats