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Aim: To investigate the expression of p63 protein and ki67 antigen in a series of graded OSCC to evaluate the potential association between the expression of the two markers and the aggressiveness of histologic grades of OSCC. Methods: Hematoxylin and Eosin (H&E) and streptavidin-biotin immunoperoxidase staining techniques was used to detect the expression of p63 & ki67 in different grades of OSCC. Evaluation of immunostaining was done using computer image analyzer system & statistical analysis. Results: regarding p63 & ki67 expression were obtained by comparing the area % between different grading of OSSC, there was a statistically highly significant difference between different grades of OSCC (P<0.01) & there was a statistically significant direct correlation between p63 & ki67 stain. Conclusion: These results suggest that p63 & ki67 could reflect biological features, such as proliferation and differentiation for recognition of clinical behavior of OSCC also p63 & ki67 alteration may be associated with the progression of these neoplasms.

p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma