English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective: The aim of this study was to evaluate the application of platelet rich fibrin on the outcome of mandibular fracture. Methods: This prospective study was carried on 16 patients with mandibular angle fracture with a mean age of 35 years, PRF was applied on fracture line after reduction. Results: significantly higher mean of bone density was recorded in PRF group in first and third months postoperatively. Conclusion: PRF seems to be attributed to enhance and accelerate bone formation. (3278) Heba T. Allah M. Fayed E.D.J. Vol. 65, No. 4 splints, circum-mandibular wiring, and extra-oral pins. Semi-rigid fixation with transoessous wiring and miniplates to rigid fixation. In recent years the treatment of mandibular fractures has led to the use of operative as well as conservative methods. Apart from conservative measures, several surgical methods may be applied to treat mandibular fractures. There is no general agreement on specific line of treatment for mandibular fractures due to wide variation of osteosynthesis methods in use (4, 5). Angiogenesis which is supported by cytokines such as platelet derived growth factor (PDGF), fibroblast growth factor (FGF), transforming growth factor beta (TGFβ), vascular endothelial growth factor (VEGF) and bone morphogenic proteins (BMP). These cytokines are all involved in osteogenesis and angiogenesis, platelets contain a large number of growth factors and cytokines that have a key role in bone regeneration and soft tissue maturation(6, 7). Platelet rich fibrin (PRF) , developed in France by Choukroun(8) , is a second generation platelet concentrate that accelerate healing of hard and soft tissue. It is characterized by easy preparation and application, less expense and no biochemical modification (without bovine thrombin compared with platelet rich plasma (PRP) that require anticoagulant) . PRF is a strictly autologous fibrin matrix containing a large amount of platelet and leukocyte cytokines. Many in vitro studies have assessed the effects of PRF membranes on the proliferation of large variety of cells, and the influence of leukocytes on both cell reactions and growth factors release were already hypothesized PATIENTS AND METHODS This is a prospective study carried on 16 patients with mandibular angle fracture with age ranged from 18 to 52 with a mean age of 35 years. Inclusion criteria include patients with mandibular angle fracture (either isolated or associated with symphseal, parasymphseal or body fractures), with displacement of the fracture segments so the surgical intervention is necessary . Treatment was performed within one week of the fracture occurrence. Exclusion criteria include associated condylar, ramus or coronoid fractures, infected, comminuted mandibular fractures, fractures existed for more than one week, non union and malunion fractures and patients with severe systemic diseases that may not represent a good candidate for surgical intervention. Personal, past medical and past dental history were obtained for each patient, followed by extra and intra oral clinical examination. Radiographic examination include digital panoramic radiographs and computed tomography examination for accurate assessment of number and location of fracture lines, degree of displacement, detection of the inferior alveolar canal and presence of a tooth within the fracture lines . Preoperative preparations including ECG, chest radiographs and coagulation profile were performed for each patient. The patients were informed about the nature of the surgery including the intra-operative and the postoperative complications and a written informed consent was signed by all the patients prior to surgery. Patients within the current study were equally divided into two groups; patients within group (1) were treated by open reduction and fixation using mini plates followed by application of PRF on fracture line. Patients within group (2) were treated by open reduction and direct osteosynthesis using one or two mini plates. Operative procedures Exposure of fractured mandibular angle was performed through a submandibular approach, the fracture segments were reduced using a bone clamp, and fixation was achieved using one or two 2.0 mm miniplates with at least two conventional screws on each side of the fracture line. AUTOLOGOUS PLATELET RICH FIBRIN GLUE LOCAL APPLICATION (3279) Preparation of Platelet rich fibrin (PRF) PRF was prepared according to the Choukroun’s et.al technique, 10 ml of venous blood was collected in a sterile dry glass tube without an anticoagulant, centrifuged immediately at 3000 rpm for 10 minutes, this step is performed twenty minutes before the surgery, then the platelet poor plasma which accumulated at the top was discarded, PRF was carefully dissected approximately 2 mm below its connection to the red corpuscle beneath to include remaining platelets, which have been proposed to localize below the junction between PRF and the red corpuscle. The obtained PRF glue was locally applied at the fracture site for patients within group (1) prior to insertion of the fixation screws. Post operative assessment Clinical and radiographic examination was performed immediately postoperative for evaluation of proper reduction of the fracture and stability of the fracture segments. Patients were recalled for up to six months follow up period with one and three months intervals. During the follow up period, patients were clinically assessed for range of mandibular movements by measuring of the maximum interincisal mouth opening, ensuring proper occlusion by checking maximal intercuspal relationship, presence of postoperative signs of infection related to soft tissue or hardware, stability of the fractured segments, malunion or nonunion. Radiographic follow up Digital panoramic radiographs was performed for radiographic evaluation at the follow up intervals. A qualitative analysis: for evaluation of alignment of the fractured segments and fracture line width. A quantitative analysis: Radiodensitometric analysis were performed to the digitized images using Digora specially designed software. For standardized selection of the point of interest position to be under investigation, calculation of X and Y exact coordinates for a two points A and B was performed and repeated during the follow up radiographs. The point A was selected at the fracture line and the point B was selected 5 mm at the same level of the first point but located within the sound bone. Then, the pixel density of these two points were measured according to each point’s radio-opacity. The bone density (pixel density) was calculated as the difference between the pixel density of the two points (point A) representing at the fracture line and (point B) at sound bone.

Autologous Platelet Rich Fibrin Glue Local Application at Fracture Line in Treatment of the Mandibular Angle Fractures