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Aim: Discovering the antibacterial behavior of Salvadora persica roots Nanoparticles versus sodium hypochlorite. Methods: 22 extracted anterior teeth adjusted for 18 mm length standardization. The root canals were initially prepared using manual instrumentation till size 25 for apical preparation. Sterilization of the samples was done using gamma rays. After sterilization, the samples were then divided into two groups (with n=11) according to the tested irrigating material used as follow; Group1: 2% sodium hypochlorite and Group 2: Salvadora persica roots nanoparticles. Mechanical preparation was accomplished by Revo-S system from crown to the apex. Counting of the E. Fecalis was done before and after irrigation by determining the Colony Forming Unit. Results: The highest value of percentage changes in bacterial reduction was in Group 1 (Ninety four percentage) and the least bacterial reduction percentage was found in (Group 2) (Eighty five percentage) with no significant difference statistically between both groups. Conclusion: Salvadora persica roots nanoparticles is a promising irrigating solution of herbal origin. (832) Elsaeed Abdel Hafez and Amgad H. Soliman E.D.J. Vol. 65, No.

ANTIBACTERIAL EFFECT OF SALVADORA PERSICA ROOTS NANOPARTICLES VERSUS SODIUM HYPOCHLORITE AS ROOT CANAL IRRIGATION