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Objective: cancer result from abnormal genetic makeup of a cell resulting in continuous celldivision with often production of metastasis throughout the body. Apoptosis is very effective inkilling cancer cells. We performed this study to investigate the effect of annonaceae and 5FU drugnanoparticles against scc-25 cell lines human tongue squamous cell carcinoma by studying theireffect on cell cycle progression and apoptosisMethods: Cell Line cells were obtained from American Type Culture Collection , cells werecultured using DMEM (Invitrogen/Life Technologies). Annonaceae nanoparticles and 5FU drugwere used. The effect of the tested materials were investigated by MTTassay, cell cycle analysis &flow cytometry.Results: the cancer cells treated by annonaceae nanoparticles revealed obvious cytotoxicity atiC50 7 μg/ml, in addition it stimulated the upregulation of annexin-v leading to apoptosis of cancercells and growth arrest at G1 phase with prominent late apoptosis analyzed by cell cycle analysis& flow cytometry.Conclusion: Our findings demonstrate that annonaceae nanoparticle might be capable ofinducing cancer cell death against SCC-25 cell lines by cell cycle arrest and induction of apoptosis.

egyptian dental journal /egyptian dental journal

Investigation the Cytoto xicity and Apopto sis of annonaceae nanopartic les and 5-FU encapsulated chito san nanopartic les against Tongue Squamous Cell carcinoma Cell Lines (SSC-25)