English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background and objective: Bone substitutes are widely used to promote bone formation and periodontal regeneration. The aim of this study was to compare the clinical and radiographic effectiveness of cortico-cancellous bone mix xenograft (Osteobiol Gen-Os) in the treatment of intrabony defects. Materials and methods: Twenty systemically healthy chronic periodontitis patients, radiographic observation showed vertical intrabony defect of ≥ 5 mm after non-surgical periodontal therapy, subjects were categorized into group 1 (G1) treated by xenogrfat and group 2 (G2) treated by open flap debridement only. At baseline, 6 and 12 month after surgery the patients were evaluated clinically by: plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL), and radiographically to measure the bone density and reduction of intrabony defect depth. Results: Significantly clinical improvements of PI and GI were observed in both groups. In G1, The mean values of PD and CAL were representing highly significant differences between the three time intervals (baseline, 6 and 12 month, (P ≤ 0.01). In G2, the statistical comparisons between the mean values of PD at 3 time intervals, also CAL mean values at 6 month versus baseline were highly significant (P ≤ 0.01). Radiographically, the bone density and reduction of defect depth were improved in G1 compared to G2. The mean values of bone density and reduction of defect depth were high significantly increased in G1 versus G2 at 6 and 12 month (P ≤ 0.01). Conclusions: The results of the current study indicated that cortico-cancellous xenograft (Osteobiol Gen-Os) significantly improved of clinical and radiographic outcomes over the course of the study. (1410) Alaa Moustafa Attia E.D.J. Vol. 63, No. 2 Numerous bone graft materials are used therapeutically, including xenografts, which are materials obtained from other species with their organic components totally removed. Removal of the organic components prevents immune reactions by the host. The remaining inorganic structure provides a natural matrix and a perfect calcium source. (2) Heterologous cortico-cancellous bone mix xenograft (OsteoBiol Gen-Os), it is biocompatible and bioavailable, Gen-Os is gradually resorbable and provides support in bone neoformation helping to preserve the original graft shape and volume. Furthermore, advantage to its collagen content, the product enhances blood clotting and the subsequent invasion of regenerative cells. Because of its marked hydrophilia, it can be used as a carrier for selected medication and drugs. The particle sizes of the commercialized product are 250–1,000 μm and its porosity is 33%. (3) The material exhibited good clinical findings when used for augmentation of the alveolar crest and maxillary sinus, as filler in postextractive alveolus and for implant treatment. (4,5,6) Clinical and histological study suggest that the use of collagenated porcine bone (OsteoBiol Gen Os) as a grafting material can lead to the augmentation of the alveolar crest or the maxillary sinus floor prior to or in conjunction with implant placement. (7) Long-term assessment of bone formation in response to Gen Os xenograft in an experimental rat model was studied by Develioglu H et al., (2015); they reported that Gen Os has osteoconductive and biocompatible effects. Based on the long-term outcomes, Gen-Os xenograft is more beneficial to bone regeneration, but further studies are needed. (8) Recently, Rombouts et al., (2016) studied the angiogenic potential of xenogenic bone grafting materials (Gen-Os of equine and porcine origins, and anorganic Bio-Oss) in periodontal ligament cells culture. Both Gen-Os materials significantly improved secretion of vascular endothelial growth factor (VEGF) by periodontal ligament cells cells. On the other hand, significant increase in endothelial cell proliferation was observed in cultures with both Gen-Os conditioned media, but not with that of Bio-Oss. (9) According to our knowlodge there is no studies are presently available for the treatment of periodontal intrabony defects by Cortico-cancellous xenograft [Osteobiol Gen-Os]. The purpose of the present study was to investigate the collagenated heterologous corticocancellous bone mix xenograft (osteobiol; Gen-Os) versus to open flap debridement (OFD) in treatment of human periodontal intrabony defects. MATERIALS AND METHODS

egyptian dental journal /egyptian dental journal

CLINICAL AND RADIOGRAPHIC EVALUATION OF CORTICO-CANCELLOUS BONE MIX XENOGRAFT (OSTEOBIOL GEN-OS®) IN THE TREATMENT OF HUMAN PERIODONTAL INTRABONY DEFECTS