English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Oxidative stress and accumulation of reactive oxygen species may play a role in the pathogenesis of cancer. They were reported in precancerous and cancerous cells.   Methods: An animal model of carcinogenesis was used to detect the effect of oxidative stress on mitochondrial ultrastructure by transmission electron microscope and the levels of extracellular signal- regulated kinase-1(ERK-1) and hypoxia inducible factor-1 alpha (HIF-1α) by immunohistochemistry in mild and severe oral epithelial dysplasia (OED) induced in tongues of experimental mice.   Results: We identified degeneration and enlargement of mitochondria in association with up- regulation of both ERK-1 and HIF-1α from normal control to mild OED and reached their highest values in severe OED.   Conclusions: Degeneration and enlargement of mitochondria in association with up-regulation of both ERK-1 and HIF-1α can be indicative features of dysplastic changes and may act as early markers for malignancy.

egyptian dental journal /egyptian dental journal

THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS