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The problem of repeated miscarriages affects 0.5-2% of population. The current case is with history of 15 unexplained miscarriages following both, spontaneous conceptions and after IVF. All the routine investigations were normal. She had been treated with all the established methods of treatment without success. She was diagnosed with allo-immune cause of miscarriages and was given Lymphocyte Immunization Therapy (LIT). Her pregnancy successfully went till term. There were no side effects of the LIT to the mother or the baby. A case with higher number of repeated miscarriages is more likely to be due to allo-immune rejection of pregnancy. Immunomodulation with active immunotherapy in the form of LIT is still an effective therapy in properly selected cases.

Role of immunomodulation with lymphocyte immunization therapy (LIT) in a couple with 15 unexplained repeated miscarriages