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Gum arabic is a polysaccharides obtained from the stems and branches of Acacia senegaltree. In folk medicine Gum arabic has been reported to have anti-oxidant and nephroprotectant effects. This study aimed to evaluate the Gum arabic effect on kidney dysfunction in chickens which induced by cadmium nitrate. Healthy chickens were divided into three groups, 5 chickens in each group; group 1: Normal group fed on basal diet, group 2: Control group feed on basal diet mixed with (100 ml/kg b. w.) cadmium nitrate, Group 3: Treated group, chickens feed on basal diet mixed with cadmium nitrate (100 ml/kg b. w.) then treated with Gum Arabic extract (500 g/kg body weight). . Blood samples were collected at the beginning of the experiment (group 1: normal), after 5 days blood samples collected from (group 2: control) and after 10 days of Gum Arabic treatment blood samples collected from (group 3: treated), creatinine and uric acid were estimated as a kidney function parameters. The results demonstrated that oral administration of cadmium nitrate (control group) recorded a significant increase at (p<0.05) in serum creatinine levels and serum uric acid levels compared with those levels of the normal group. The results in this study illustrated that oral administration of Gum Arabic extract (treated group) showed a significant decrease at (p<0.05) in serum creatinine level and serum uric acid level compared with those levels of the normal group Furthermore, the results obtained from this study suggested that oral administration of Gum Arabic extract may be helpful in the prevention of kidney dysfunction and may represent an effective therapy that normalizes serum creatinine and serum uric acid levels in chickens.

egyptian academic journal of biological sciences. c, physiology and molecular biology/egyptian academic journal of biological sciences. c, physiology and  molecular biology

The Effect of Gum Arabic in Treatment of Kidney Dysfunction in Chickens