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Caspase-3 Gene is a unique protease enzyme involved in the initiation and execution of apoptosis process. The aim of this study to investigate the mRNA expressions of caspase-3 on experimentally induced colorectal cancer (CRC) in male albino rats, rats treated with adipose tissue mesenchymal stem cells (MSCs) and curcumin. Forty white male albino rats were divided into four groups 10 in each, Control group (1st): They received 0.5 ml of 25% DMSO orally once daily, while the other three groups were injected subcutaneously with dimethylhydrazine (DMH) at a dose of 20 mg/kg body weight per week for 4 consecutive weeks. After two weeks of the last DMH dose, the 2nd Group: left injected with DMH only, the 3rd group: every rat received one million cells of MSCs interperitoneally once. The 4th Group:  received oral curcumin at a daily dose 100 mg/kg body weight for two weeks. The colon tissue homogenate caspase-3 mRNA expression was assayed by (real-time PCR). Caspase-3 expression level was significantly decreased in the DMH group than that of the control group while it was significantly increased in DMH+MSCs and DMH+curcumin treated groups in comparison with a DMH group. Mesenchymal stem cells and curcumin thought to have an ameliorative effect on colorectal cancer in male albino rats. Thus the development of CRC may involve changes in the mRNA level of the caspase-3 gene.

egyptian academic journal of biological sciences. c, physiology and molecular biology/egyptian academic journal of biological sciences. c, physiology and  molecular biology

Expression Level of Caspase-3 Gene in Colorectal Cancer Induced by Dimethylhydazine and Potential Therapeutic Role Of Mesenchymal Stem Cells and Curcumin.