English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Spirulina platensis have therapeutic functions such as antioxidant, anti-bacterial, antiviral, anticancer, anti-inflammatory, anti-allergic and anti-diabetic. The purpose of this study was to evaluate the protective effect of spirulina platensis on L-methionine induced hyperhomocysteinemia (HHcy) in rats. Thirty male albino rats were divided into three equal groups. Group I (control normal): rats administered distilled water. Group II (hyperhomocysteinemic group (HHcy): rats received L-methionine (1.7 gm/kg body weight/day) orally for continuous 8 weeks. Group III (HHcy + spirulina platensis): rats received spirulina (1.5 gm/kg body weight/day) orally for 4 weeks after induction of hyperhomocysteinemia. The obtained results showed significant increase in serum homocysteine, lipids profile (total cholesterol and triacylglycerols), liver marker enzymes (ALT, AST and ALP), liver L-MDA and pro-inflammatory cytokines (TNF-α and IL-8) gene expression level in hyperhomocysteinemic (HHcy) rats. However, liver SOD activity and GSH concentration were markedly decreased. Spirulina treatment to L-methionine induced HHcy in rats caused significant improvement of all previous parameters towards its normal ranges. These results suggested that, spirulina treatment exerts a protective effect on HHcy by reduction of oxidative stress marker, inflammation and hyperhomocysteinemia in rats through free radical scavenging and anti-inflammatory activities as well as regenerating endogenous antioxidant defense system mechanisms.

benha veterinary medical journal

Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats