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In the present study an inactivated tissue culture adapted RVF virus vaccine was prepared using Montanide oil IMS 1313 nanoparticles as adjuvant then evaluated in sheep in comparison to the local RVF virus vaccine with aluminum hydroxide gel adjuvant using serum neutralization test (SNT) and Enzyme Linked Immuno-Sorbent Assay (ELISA). The prepared vaccine was sterile and safe inducing no systemic or local clinical signs in sheep. Results indicated that the prepared nanoparticles oil based vaccine induced a protective neutralizing serum antibody titer from the 2 nd week post vaccination (WPV), reached the highest level at the 3 rd month post vaccination (MPV) and persisted in protective level until the for 9 th MPV, while aluminum hydroxide gel based vaccine appeared in protective level at 2 nd WPV, reached the highest level at the 2 nd MPV and persisted in protective level till the 7 th MPV. These results were confirmed by using ELISA. These results demonstrated the potentiality of the prepared nanoparticles oil based vaccine compared to the locally produced aluminum hydroxide gel based vaccine reflected by greater immunogenicity and longer duration of immunity.

benha veterinary medical journal

Evaluating humoral immune response of sheep vaccinated with inactivated RVF virus vaccine using oil nanoparticles adjuvant in comparison with aluminum hydroxide gel