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Hyperlipidemia is a known risk factor for the development of cardiovascular disease including atherosclerosis. The present study was carried to evaluate the protective effects of alpha-lipoic acid against hyperlipidemia induced in rats fed high fat diet. Hundred male albino rats were divided into four equal groups. Group I:(control normal group) rats fed on normal diet. Group II: (hyperlipidemic group) rats fed hyperlipidemic diet (1% cholesterol, 0.5 % cholic acid and 5% hydrogenated fat/kg diet) for 8 weeks. Group III :( hyperlipidemia +Alpha-lipoic acid group) rats fed hyperlipidemic diet and treated with alpha-lipoic acid (54 mg/kg b.wt/day/ i.p). Group IV: (Alpha-lipoic acid group): normal rats treated with alpha-lipoic acid (54 mg/kg b.wt/day/ i.p). Blood samples for serum separation were used for total cholesterol (TC), triacylglycerol (TG), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), very low density lipoprotein-cholesterol (VLDL-c), phospholipids, glucose and insulin determination. In addition, liver tissue were processed for the determination of L-Malondialdhyde (L-MDA), catalase (CAT), superoxide dismutase (SOD) and reduced Glutathione (GSH). The obtained results revealed that, a significant increase in serum TC, TG, HDL-c, LDL-c, VLDL-c, glucose and insulin resistance in addition to liver L-MDA concentrations were observed hyperlipidemic rats. However, administration of alpha-lipoic acid exhibited a significant decreased in all mentioned parameters. On the other hand, serum phospholipids, antioxidant enzymes and GSH in liver tissue were significantly decreased in hyperlipidemic rats. Meanwhile, treatment with alpha-lipoic acid to hyperlipidemic rats resulted in significant increase in liver CAT activity and GSH concentrations. It could be concluded that, alpha lipoic acid has the potential in improving dyslipidemia and oxidative stress and may exert some protective effect on atherosclerotic vascular change in hyperlipidemic rats.

Biochemical study on the effect of alpha-lipoic acid on lipid metabolism of rats fed high fat diet