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Background: Recent data have emerged that a targeted biopsy technique using Narrow-Band Imaging (NBI) could be considered in patients undergoing surveillance for Barrett’s esophagus (BE). Aim of the study: to determine the role of NBI compared to conventionalwhite light endoscopy (WLE) in diagnosis of Barrett’s esophagus in patients with chronic gastroesophageal reflux disease. Patients and methods: the study included 274 patients with chronic reflux symptoms, conventionalwhite light endoscopy (WLE) was done in all cases for diagnosis of BE. Ninety patients showed Barrett’s mucosa pattern by white-light endoscopy so 4-random biopsies were taken and examined by histopathology for detection of columnar-lined intestinal metaplasia, then patients who showed negative histopathology for intestinal metaplasia were re-endoscopied and NBI targeted biopsies were taken for histopathological confirmation of presence of intestinal metaplasia. Based on histopathology results, patients were divided into 2 groups, group 1 (B E positive, 80 patients) and group 2 (BE negative, 10 patients). Group showed increased detection rates in age > 30 years. Results: 90 patients had columnar-lined epithelium (CLE) by WLE (32.8%); Seventythree patients with 4 quadrant biopsy technique confirmed to have intestinal metaplasia (81.1% of cases with endoscopic BE, and 26.6% of all screened patients), 17 patients with negative histopathology for BE were re-examined endoscopically and NBI targeted biopsies were taken, 7 patients of them showed intestinal metaplasia, so total patients confirmed to have BE has risen to 80 patients (88.9%). Conclusion: NBItargeted biopsies could diagnose BE in patients tested negative by WLE taken biopsies

Role of NBI and WLE in diagnosis of Barrett’s esophagus in patients with chronic gastroesophageal reflux disease