English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Ulcerative colitis (UC) is one of the inflammatory bowel diseases (IBD) that results in recurrent inflammation and ulcers of the colon and rectum. Aim: The aim of the study was to explore the possible therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) and vitamin E on experimentally induced UC in rats. Materials and methods: Sixty rats were divided into five main groups: group I (control group); group II (UC) consisted of 10 rats that received a single intrarectal injection of 2 ml of 3% acetic acid; group ΙIΙ (10 rats) consisted of rats that received vitamin E three times in a week orally after induction of ulcerative colitis; group ΙV consisted of 10 rats that received a single injection of BM-MSCs after induction of ulcerative colitis ; and group V comprised 10 rats that received both vitamin E orally and BM-MSCs after induction of colitis. Colonic samples were examined using light and fluorescent microscopy. Results: Group ΙI showed ulceration, loss of surface columnar epithelium, disturbed crypts architecture with few goblet cells and many cellular infiltrations. Group III showed a picture that was nearly similar to UC group. Group IV showed improvement in colitis. Group V showed a histological picture that was nearly similar to the control group. Conclusions: BM-MSCs represent future therapeutic hopes for chronic intestinal inflammatory states through their regenerative and anti-inflammatory effects. The combination of vitamin E and BM-MSCs was more effective and produced an additive effect than using bone marrow derived MSCs alone.

benha medical journal

The possible therapeutic Effect of Mesenchymal Stem Cells and Vitamin E on Experimentally Induced Ulcerative Colitis in Adult Male Albino Rats: Histological and immunohistochemical study