English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Myocardial infarction (MI) continues to be associated with high morbidity and mortality worldwide. Proton Pump inhibitors (PPIs) exhibit cardioprotective effects by several mechanisms. Vitamin E possesses antioxidant properties. Aim: The present study has been designed to evaluate the combined cardioprotective effect of PPIs and vitamin E on biochemical and histopathological alteration in isoprenaline (ISO) induced myocardial infarction in rats. Methods: 30 adult Wistar albino male rats divided into 5 groups as follow: Group I: Control fed a standard diet.Group II: rats were undergoing MI by ISO. Group III: Rats were pretreated pantoprazole (1.3 mg/kg, i.o) daily for 3 weeks. Group IV: Rats were pretreated with vitamin E (100 IU/kg i.o) daily for 3 weeks. Group V: Rats were given both pantoprazole (1.3 mg/kg, i.o) and vitamin E (100 IU/kg bw, i.p) daily. On 22thand 23th day, rats in groups (II-V) were injection i.p with ISO (100mg/kg bw for successive two days). Results: ISO induced infarction in rats resulted in a significant elevation in ST segment height, T – wave voltage, Heart rate (HR), serum lactate dehydrogenase (LDH), malondialdehyde (MDA) and nitric oxide metabolites (NO), whereas it caused a significant (P < 0.05) decrease in systolic blood pressure(SBP) and serum superoxide dismutase (SOD) when compared with the control group. Moreover, interventions with PPIs supplementation and/or vitamin E significantly reversed the aforementioned parameters with better impact of their combination. Conclusion: PPIs combined with vitamin E exert potential protective effect against MI through lowering calcium overload and enhancement of antioxidant activity.

benha medical journal

Effect of Proton Pump Inhibitors, Vitamin E and their co- administration on heart function and Oxidative Changes in Isoprenaline Induced Myocardial Infarction in Adult Male Albino Rats