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Background: Infertility is one of the most effective problems facing advanced and developed nations. In general, about half of all cases of infertility are caused by factors related to the male. Up till now, there is no effective treatment for patients with azoospermia, in which there is an absence of mature sperm in the testes. Although evidence suggests that many patients with male infertility may be treated with MSCs. Aim: Our study aims to investigate the effect of honey, bovine colostrum, G-CSF on homing of HSCs from their niche for treatment of induced fertility in male mice. Materials &Methods: Seventy male mice were randomly divided into seven groups and injected with cyclophosphamide to be infertile , then first group treated with honey, second treated with bovine colostrum ,third treated with MSCs, fourth treated with G-CSF , fifth treated with wheat germ , the 2nd generation of stem cells were injected intraperitoneally. Different samples were taken at the end of study for tests. Results: Azoospermatic male mice expressed SCP-3, GFRa1, Sca-1, Protamine and Prohibitin in testis tissue after treatment. Expression of SCP-3, GFRa1, and sca-1 in testis of azoospermatic male mice induced with cyclophosphamide after treatment with honey,bovine colostrum and umbilical cord derived mesenchymal stem cells.

biochemistry letters

Treatment of cyclophosphamide induced infertile male mice with HSCs that homed by honey, bovine colostrum and umbilical cord blood derived mesenchymal stem cells