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Role of Echo and Tissue Doppler in Patients with Down Syndrome in Absence of Congenital and Acquired Heart Disease A.M.Ezzat, E.H.Asar, E.G.El-Rahman and A.F.Abd El-Ghafar Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt E-Mail:Ahmed256@gmail.com Abstract To study the cardiac functions in Down syndrome children who did not have structural cardiac lesion by conventional and tissue Doppler echocardiography. Materials and methods: A total of 115 children with Down syndrome without anatomic heart disease and 55 normal control children were subjected to the assessment of right and left ventricular functions by both two-dimensional and tissue Doppler echocardiography. Ds might have been diagnosed Eventually Tom's perusing a karyotype test. Patients for morus rubra kind were not incorporated in this consider. Youngsters for down syndrome needed fundamentally higher cleared out ventricular launch portion distinguished Toward two-dimensional echocardiography Also left ventricular diastolic brokenness distinguished by tissue doppler over watched in the controls. On addition, Youngsters for down syndrome additionally needed correct ventricular systolic and diastolic dysfunctions. Kids for down syndrome needed essentially higher pulmonary conduit systolic weight over those control Youngsters These discoveries recommend customary tissue doppler Furthermore two-dimensional echocardiography were handy systems of investigating ventricular capacity and recognizing An higher occurrence for biventricular brokenness On patients with down syndrome compared with those solid controls.