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Two simple and sensitive spectrophotometric and spectrofluorimetric methods have been described for the determination of trimetazidine dihydrochloride in bulk and dosage forms. The first method depends on ion pair complexation between the cited drug with two dyes; tropaeloin 000 and methyl orange in aqueous medium. All variables affecting the formation of complex were studied and optimized. The coloured products of the drug with tropaeloin 000 and methyl orange were measured at 490 nm and 422 nm respectively, after extraction with chloroform. Beer’s law was obeyed in the concentration ranges 4-20 μg ml and 2-12 μg ml for tropaeloin 000 and methyl orange respectively. The spectrofluorimetric method depends on the condensation of malonic acid and acetic anhydride under the catalytic effect of trimetazidine dihydrochloride. The condensation product gave two emission maxima measured at 452 nm (λex 393 nm) and 470 nm (λex 428 nm). Variables affecting this condensation reaction were studied and optimized. At both maxima of emission good correlation was observed in the range 40-200 ng ml. The proposed methods were applied successfully for the determination of the cited drug in tablet dosage form without interference from common encountered additives. Percentage recoveries ranged from 98.9% to 99.7% in bulk and 96.9% to 98.3% in tablet dosage forms analysis.

SIMPLE SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC METHODS FOR DETERMINATION OF TRIMETAZIDINE DIHYDROCHLORIDE