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In an attempt to reduce the gastrointestinal side effects of aspirin, zinc aspirin complexwas prepared and formulated into suppositories. The prepared suppositories were evaluated invitrofor their hardness, melting range, uniformity of weight and drug content and in-vivo drugrelease.The pharmacokinetic and pharmacodynamic properties of zinc aspirin were evaluated incomparison with that of aspirin and aspirin lysinate (aspegic) following rectal and oraladministration in experimental animals. Blood samples were collected at different time intervalsafter adminstration of drugs under evaluation. Salicylic acid (main metabolite of aspirin) wasdetermined in plasma by using high performance liquid chromatography (HPLC). The antiinflammatoryactivity was studied in albino rats using carrageenan oedema model; and theanalgesic activity was studied using hot plate and writhing methods.The results revealed that following rectal administration, the bioavailability of zinc aspirinwas significantly (P<0.05) greater than that of aspirin and aspirin Lysinate. The absolute bioavailabilities were 94, 88.89 and 83.63 for zinc aspirin; aspirin lysinate and aspirinrespectively. The peak plasma concentration (Cmax) were 54.5188, 50.271.68 and 48.091.15ugl-1 for zinc aspirin, aspirin lysinate and aspirin, respectively. There was significant differencein the tmax. The area under the plasma concentration-time curve (AUC) values were148.932.79, 140.832.3 and 132.493.56 ug.h/ml for zinc aspirin, aspirin lysinate andaspirin, respectively. There were significant differences in the Cmax, tmax and AUC following oraladministration. The anti-inflammatory and analgesic studies revealed that zinc aspirinadministered rectally or orally was more effective as anti-inflammatory and analgesic. The invivostudies were correlated with the in-vitro release studies of aspirin from the preparedsuppositories.Based on the obtained results, the authors recommend the possible use of zinc aspirin as asubstitute of aspirin containing products.

PHARMACOKINETICS AND PHARMACODYNAMICS EVALUATION OF PREPARED ZINC ASPIRIN SUPPOSITORIES