English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: To study the effect of swimming exercise training on plasma irisin level and browning of white adipose tissue in rats models with obesity or type 2 diabetes mellitus (T2DM). Methods: 60 male rats were d ivided into 4 groups, I) Control group, II) Exercise trained group, III) Obese group: includes 2 subgroups; subgroup A received high-fat diet and subgroup B received high-fat diet associated with daily exercise training and IV) Type 2 diabetic group: includes 2 subgroups; subgroup A and B. Both subgroups have T2DM. Subgroup B, in addition, was associated with daily exercise training after induction of T2DM. Plas ma samples were analyzed for irisin, fasting insulin, fasting blood glucose and lipid profile. Levels of uncoupling protein-1 in subcutaneous abdominal ad ipose tissue homogenates (UCP-1 SAT) and uncoupling protein-1 in perinephric adipose t issue homogenates (UCP-1 PAT) were measured. Results: Subgroup IIIA had significantly higher irisin levels and significantly lower levels of UCP -1 SAT and UCP-1 PAT compared with group I. Subgroup IVA had significantly lower levels of irisin, UCP-1 SAT and UCP-1 PAT compared to controls. Chronic exercise significantly increased irisin, UCP-1 SAT, and UCP-1 PAT levels in group II, subgroup IIIB and subgroup IVB. Conclusion: Swimming exercise increases the plasma irisin level in normal, obese and type 2 diabetic rats inducing browning of white adipose tissue. Irisin is increased in obesity which may be attributed to a state of irisin resistance. T2DM is associated with lower p lasma irisin levels. Keywords

Effect of Chronic Exercise on Irisin Plasma Level and Browning of White Adipose Tissue in Rat Models with Obesity or Type 2 Diabetes Mellitus