English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Obesity is the number one preventable risk factor for chronic kidney disease. Multiple observational studies have documented an association between obesity and risk of kidney disease even after adjustment for obesity-related co-morbid conditions, including diabetes mellitus. Because diet specially dietary fat has been recognized as contributing to the development and prevention of obesity, the influence of quantities and qualities of dietary fat on the pathogenesis of obesity related renal disorders has been studied. It has been known that tissues of porpoise contain unique structured-lipids as combination of iso-valeric acid (iso-C5:0) and ω-3 polyunsaturated fatty acids (ω-3 PUFA). It is well known that ω-3 PUFAs have lipidlowering effects in animal and human studies. Omega3-polyunsaturated fatty acids can prevent or alleviate obesity-related disorders through the suppression of fatty acid synthesis, enhancement of fatty acid β-oxidation. In the present study the effect of structural-lipids from porpoise adipose tissue (porpoise oil) on lipid metabolism was investigated. Design In this study 4 groups of male albino rats (n=10/group): group 1 received control diet 10.6% fat, group 2 received high fat diet (HFD) 53.15% fat, group 3 received HFD 53.15% fat with porpoise oil from start of induction of obesity and group 4 received HFD 53.15% fat and followed by addition of porpoise oil for 4 weeks after induction of obesity. All groups were subjected to the assay of serum levels of total lipid profile, urea, creatinine, fasting glucose and insulin as well as the levels of free fatty acid (FFA), malondialdehyde (MDA) and nitric oxide (NO). Also, renal tissue levels of triacylglycerol (TAG), FFA, and MDA and NO as well as aldose reductase (AR) activity were assayed, with estimation of urinary albumin level. Results: There was statistically significant improvement in all parameters of renal function, oxidative stress and dyslipidemia under the effect of porpoise oil intake. Conclusions: The current results might lead us to better utilization of porpoise oil due to its content of ω-3 PUFA to reduce lipid deposition in the kidney tissue with improving its functions, therefore presenting an opportunity for developing new strategies to treat obesity.

Effect of Porpoise Oil on Kidney of Rats Receiving High Fat Diet