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Exercise practitioners often take vitamin C supplements because intense muscular contractile activity can result in oxidative stress, as indicated by altered muscle and blood glutathione concentrations and increases in protein, DNA, and lipid peroxidation. There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation. The present study was designed to study the effect of vitamin C on training efficiency in rats. Thirty male Albino rats were exercised under protocol for 6 weeks. Ten of the rats were treated with a daily dose of 500 mg/kg body weight of vitamin C (0.24 mg/cm2 body surface area). The administration of vitamin C hampered endurance capacity. The adverse effects of vitamin C may result from its capacity to reduce the exercise-induced expression of key transcription factors involved in mitochondrial biogenesis. These factors are nuclear respiratory factor 1and mitochondrial transcription factor A. Vitamin C also prevented the exercise-induced expression of the antioxidant enzymes superoxide dismutase and glutathione peroxidase. The study showed that Vitamin C supplementation decreases training efficiency because it prevents some cellular adaptations to exercise.

Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats