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Objective: The aim of the present study was to identify levels of heat shock protein 70 (Hsp 70), total immunoglobulin E (IgE) and matrix metalloproteinase-9 (MMP-9) before and after coronary artery bypass grafting (CABG) surgery. Method: Heat shock protein 70, IgE, MMP-9, creatine phosphokinase-MB (CPK-MB), and lactate dehydrogenase (LDH) levels were measured in normal subjects (n=20), and in patients with chronic stable angina pectoris who were referred for elective CABG, before and after performing CABG-surgery (n=20). Result: Compared with normal subjects, increased heat shock protein 70 and IgE levels but unchanged MMP-9 level, and activities of CPK-MB, LDH were found in the pre-operative patient group. Heat shock protein 70, and IgE levels in the post-operative period were significantly reduced when compared to pre-operative period. Conclusion: On the basis of these results it could be conclude that, heat shock protein 70 and IgE might be used as markers for detection of early minor myocardial damage, and coronary insufficiency with less overt damage than myocardial infarction, as significant changes in their levels appear before occurrence of in any changes in the levels of MMP-9, CPK-MB and LDH. Besides, heat shock protein 70, and IgE returning to the normal levels after CABG surgery, suggests that they could be helpful to evaluate the effect of CABG surgery.

bulletin of egyptian society for physiological sciences

Heat Shock Protein 70 and IgE as Inflammatory Mediators, are Early Predictors of Myocardial Ischemia and Recovery Markers after Coronary Artery Bypass Grafting (CABG)