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Indomethacin administration at a dose of 25 mg, three times a day for ninety days to a group (n: 20) of oligospermic men caused an increase in sperm count and motility, a higher level of plasma testosterone and a lower seminal prostaglandin E than the corresponding values before drug intake. The pregnancy rate was 15% (3 out of 20). The present result indicates that indomethacin could be helpful in the treatment of some cases of male infertility.

Treatment of Male Infertility Using Some Prostaglandin Synthetase Inhibitors