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This study was performed to determine the levels of plasminogen activator inhibitor-1 (PAI-1), transforming growth factor ß2 (TGFß2) and total protein in the aqueous humour of patients with glaucoma versus those without glaucoma. A total of 30 aqueous humour samples were collected from patients with glaucoma and cataract (20 glaucoma aqueous samples and 10 cataract aqueous samples). The levels of PAI1 and TGFß2 were determined by enzyme linked immunosorbent assay (ELISA), while total protein levels by the Bradford method. There was a significant increase in the aqueous levels of PAI-1, TGFB2 and total protein in the glaucoma group compared to the cataract group. Further analysis of the glaucoma group showed a significant increase in the levels of PAI-1, TGFß2 in patients with late compared to patients with early open angle glaucoma. There was a significant positive correlation between the levels of PAI-1 and total protein in patients with glaucoma. Also a significant positive correlation was detected between PAI-1 and TGFß2 in both glaucoma groups. These data are consistent with the possibility that intraocularly produced PAI-1 may contribute to glaucoma pathogenesis. So, reducing the production or activity of PAI-1 in the eye could constitute a new target for the design of glaucoma therapy.

Plasminogen Activator Inhibitor-1 and Transforming Growth Factor β2 in the Aqueous Humour of Patients with and without Glaucoma