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Background The objective of this study is to demonstrate the effects of prenatal and neonatal taking of glucocorticoid (GC) on the morphology of the pituitary gland corticotrophs and folliculostellate (FS) cells and the experssion of lipocortin 1 (LC1; annexin I) which is a mediator of many actions of GC. Material and Method Sixty adult male and female albino rats, weighting 200-230 g were used in this study pregnant and lactating rats were divided into control and treated groups (5rats per group). Treated groups with GC were given it via drinking water (1ug/ml) to the rats on d 16-19 of pregnancy or in first week following delivery for lactating rats. Results: The optical density of ACTH antibody andS100 protein antibody were significantly decreased in both prenatal and neonatal groups of dexamethasone administration compared to the control, prenatal dexamethasone treated group produce long-term changes in morphology. Also there was significant reduction in prenatal and neonatal level of annexin-1gene expression when it was compared to the control group. Conclusion: there were significant effects of GC administration in prenatal and neonatal rat groups in the form of morphological and physiological changes

Long-term effects of prenataland neonatal exposure to cortisone on the pituitary corticotrophs and folliculostellate cells in rats