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Background and objective: Diabetes mellitus affects skeletal muscle and free radicals are probably implicated in the manifestations of diabetes complications. Antioxidants have been proposed as therapeutic strategies to protect against diabetes-induced muscle dysfunction. The present study aimed to investigate and compare the effects of vitamin E or selenium on fast twitch gastrocnemius muscle of streptozotocine induced type 2 diabetic rats via recording twitch tension, time to peak tension, half relaxation time and peak tetanic tension and determination of muscle malondialdehyde and glutathione peroxidase as markers for oxidant status, specially, for our knowledge, the effects of vitamin E or selenium on contractile parameters of diabetic fast twitch muscles have not been previously investigated. Material and methods: 24 male rats of local breed were randomly divided into 4 groups (n=6), control group, diabetic group in which diabetes was induced by i.p. injection of streptozotocin 40 mg.kg , vitamin E supplemented diabetic group (600 mg.kg daily) and selenium supplemented diabetic group (5 micromole.kg daily) for 4 weeks starting 3 days after induction of diabetes. Results: Diabetes significantly reduced twitch tension and peak tetanic tension of gastrocnemius muscle with no significant change in time to peak tension and half relaxation time. Vitamin E or selenium administration to diabetic rats reversed the oxidative imbalance and improved muscle contractile status with more significant effect in selenium supplemented rats. Conclusion: Vitamin E or selenium can protect against the alterations in fast twitch muscle properties associated with diabetes.

Antioxidant treatment improves streptozotocin-induced diabetic alterations in fast twitch skeletal muscles of rats