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This work was undertaken to study the effects of progesterone on the coronary and femoral blood flow. In 18 prepubertal female dogs anesthetized with thiopental sodium, changes in the coronary and femoral flow caused by intravenous infusion of progesterone were assessed by collecting blood through Mrowtiz cannula form coronary sinus and femoral blood through a catheter inserted inside the femoral vein after ligation of the external iliac artery. In 6 dogs, infusion of 1 mg/kg of progesterone increased the coronary and femoral blood flow. The vasodilator effects of the hormone were enhanced by graded increases in the dose between 1, 2 and 3 mg/kg. The mechanisms of these responses were studied in the dogs by repeating the experiment after the arterial blood pressure and heart rate had returned to the control values before infusion. After administration of α blocker (phentolamine) or β blocker( propranolol), they did not affect the responses elicited by progesterone in the femoral blood flow. Also, injection α, β sympathetic blocker and cholinergic blocker (atropine) did not abolish the effect of progesterone on the coronary flow. Injection of N-nitro-L-arginine methyl ester (L-NAM) alone or with progesterone into the coronary or the femoral artery caused prevention in the increase in the coronary and femoral flow. The present study showed that, intravenous infusion of progesterone dilated the coronary and the femoral arteries. The mechanism of this response did not involve stimulation of sympathetic or parasympathetic vasodilator receptors, but may be through the local action.

A Study on the Effect of Progesterone on Coronary and Femoral Blood Flow in Prepubertal Female Anesthetized Dogs