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Nursing staff in the hospital are frequently the first to witness a cardiac arrest, they play a central role in the effective management of in-hospital cardiac arrest. Aim: Identifying the effect of a Basic life Support teaching Program on nurses’ Knowledge and skills at Emergency care unit. Research design: A quasi experimental research design. Setting: Emergency care medical department at Assuit University Hospitals. Sample: Nurses working in selected setting and having more than one year clinical experience. Methods: Two tools were used for data collection. Knowledge and skills assessment tools. The current study was carried out on assessment of baseline nurses’ level of knowledge and skills followed by implementation. The effect of teaching was carried out immediately after application of the program. Results: The study revealed that the majority of nurses had poor knowledge and skills related to CPR before teaching program which has been improved after teaching program. Conclusion, there was a significant improvement in the nurses' knowledge and skills related to CPR after teaching program. Recommendation annually assessment and refreshing courses to nursing staff with up- to- date guidelines to impart cognitive knowledge and psychomotor skills of CPR and to provide a standardized care to cardiac arrest patients.