English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Parkinson’s disease (PD) is the second common neurodegenerative disease and still the pharmacological treatment facing many problemsas motor complication and ineffectiveness of this treatment for most of the nonmotor symptoms. Non invasive brain stimulation (NIBS) as a new adjunctive method for treating these problems, repetitive transcranial magnetic stimulation one of NIBS techniques used in previous studies but with less consistent resultsconcerning therapeutic effect on cognitivs symptoms of PD. Aim of the work: determine whether HF-rTMS targeting LtDLPFC has beneficial effect on cognitive functions of PD patients, and if this effect present could last for longer periods after one month follow up. Patients and Methods: this randomized single blind case-control clinical study included sixty patients with idiopathic parkinson’s disease (PD) from neurology clinic of Ain Shams University hospitals in Cairo, in the period between December 2014 till December 2018. Subjects were classified according to UKPD Society Brain BankClinical Diagnostic Criteria into active and sham groups. Both groups are assessed before, immediately after completing 6 sessions of rTMS and 4 weeks after the last session. Results: This study showed moderate significant improvement ofcognitive symptoms in PD patients of active group compared to Sham group, this improvement limited to the immediately after rTMS phase not maintained in the follow up. Correlations of improvement were minimal between T2 time scores of different scales. Conclusion: HF rTMS applied over left DLPFC showed short term immediate improvement of cognitive functions of PD patients but had no long lasting effects.

ROLE OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN TREATMENT OF COGNITIVE MANIFESTATIONS IN PARKINSON'S DISEASE