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Nephrotic Syndrome (NS) is chronic disorder, characterized by alterations of the permeability of the glomerular capillary wall, resulting in its inability to restrict the urinary loss of protein. Idiopathic nephrtic syndrome (INS) ( also called nephrosis ) is defined by the combination of a nephrotic syndrome (proteinuria, hypoalbuminemia, hyperlipidemia, and edema) and non-specific histological abnormalities of the kidney including minimal changes (MC), focal and segmental glomerular sclerosis (FSGS), and diffuse mesangial proliferation. As INS response to treatment with steroids varies ,several studies was done to analyze the association between patient genetic profile and the response to steroid treatment, which help in predicting the treatment response of children with INS.. Nowadays it is clear that NR1I2 gene is also involved in regulation of steroid metabolism through trans-activation and trans-repression of genes controlling glucose, lipid, cholesterol, bile acid, and bilirubin homeostasis.

STUDY OF NR1I2 GENE POLYMORPHISM (A7635G) AND STEROID RESISTANCE IN EGYPTIAN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME