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In this study, novel 3-substituted 1,2,4-triazino[6,1-b]quinazolines 4a-e, 8substituted-1H-[1,2,4]triazino[6,1-b]quinazoline-2,4,10(3H)-triones 8a&b and 2substituted 1,2,4-triazino[6,1-b]quinazolines 9a-d, 10 & 11 were synthesized from 3amino-6-bromo-2-ethoxycarbonylquinazolin-4(3H)-one (2b) and 3-amino-2aminocarbonylquinazolin-4(3H)-one 7a&b. Some of the newly synthesized compounds were tested for their antimicrobial activity and analgesic activity. Depending on the obtained results, the newly synthesized compounds possess significant analgesic activity and mild antimicrobial activity. Introduction Quinazoline derivatives have been reported to possess diverse biological activities such as analgesic (Alafeefy et al., 2010), anti-inflammatory (Alagarsamy et al., 2007; Chandrika et al., 2008; Giri et al., 2009), antimicrobial (Minu et al., 2008; Panneerselvam et al., 2009; Ryu et al., 2012) and anticancer (Noolvi et al., 2011 and Mulakayala et al., 2012). In addition 1,2,4-triazine derivatives were found to possess antimicrobial activity (Taha M.A.M., 2007 and Elsilk et al., 2010), antitumor activity (Gucky ́ et al., 2010). Finally, condensed [1,2,4]triazinoquinazoline were reported to have antibacterial and antifungal activity (Abdel-Mageed et al., 1988; Abdel-Hamide et al., 1997; Abdel-Hamide, 2001; Ghorab et al. 2013), anti-inflammatory activity (Bansal et al., 2001 and Hussein, 2012), anticancer activity (Kovalenko et al. 2013) and analgesic activity (Pathak et al. 1995). The above findings directed the attention to the synthesis of certain substituted [1,2,4]triazino[6,1-b]quinazoline hoping that they may possess antimicrobial activity and analgesic activity.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.