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Background: Insecticides occupy a rather unique position among many chemicals that man encounters daily, in that they are deliberately added to the environment for the purpose of killing or injuring some form of life. Vitamin C consider as antioxidant substance which has a protective role against deleterious effects of Diazinon and Aluminium phosphide. The aim is to evaluate effects of Diazinon, Aluminum phosphide and vitamin C on liver, kidney and brain of albino rats. Results: data shows a significant increase in liver enzymes AST, ALT in addition to GGT and ALP by the action of the used pesticides Diazinon and Aluminum phosphide also this pesticides cause a significant increase in serum urea, uric acid and creatinine while the histological study showed that the chronic treatment with doses of the insecticides induced different deleterious histopathological lesions in the brain of treated rats. The treatment using vitamin C cause amelioration in liver functions tests and kidney functions tests, although, all these tests did not show any significant decrease. Conclusion: Vitamin C can ameliorate the deleterious effects of Diazinon and Aluminum phosphide on liver and kidney.

al-azhar journal of pharmaceutical sciences/al-azhar journal of pharmaceutical sciences

THE PROTECTIVE ROLE OF VITAMIN C AGAINST PHYSIOLOGICAL AND HISTOLOGICAL CHANGES IN RATS CHRONICALLY EXPOSED FOR DIAZINON AND ALUMINUM PHOSPHIDE INSECTICIDES.