Effect of Simvastatin and Antioxidant Mix on Pulpotomized Young Permanent Teeth: A Clinical and Radiographic Study

Objective: The objective of this study was to evaluate, clinically and radiographically, the effect of Simvastatin and Antioxidant mix on pulpotomized young permanent teeth. Subjects & Methods: Pulpotomy was performed in 54 vital decayed young permanent molars that were indicated for vital pulp therapy. The molars were classified randomly into three equal groups: Group A: molars receiving Simvastatin after pulpotomy (n=18); Group B: molars receiving Antioxidant mix after pulpotomy (n=18); Group C: molars were receiving calcium hydroxide after pulpotomy (n=18). The treated teeth were followed up clinically and radiographically after variable intervals (immediately, 1 month and 3 months) after treatment. The assessment of treated teeth was performed by visual inspection of the signs and symptoms and by periapical radiographs for assessment of pulp space, lamina dura and periapical tissue. Result: According to pain, mobility, swelling, internal or external resorption, widening of periodontal ligament and periapical radiolucency; in simvastatin group at 3 months, 15 (83.3%) of cases were successful and 3 cases failed. Antioxidant mix, at 3 months, 16 (88.9 %) of cases were successful and 2 cases was failed. Calcium hydroxide, at 3 months, 16 (88.9%) of cases were successful and 2 cases failed. Conclusion: Simvastatin and Antioxidant mix pulpotomy are more costeffective, handled easilily, and biocompatible. It has been proven potentially to be an ideal pulpotomy agent in the treatment of vital young permanent teeth. All three tested materials enhancing root formation “elongation” without significant difference, without any change in periodontal tissue.