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Background: in Egypt, Breast carcinoma is the most common malignancy affecting women. It is claimed for 32 % of cancer in women. It is essential to clarify and assess prognostic factors associated with the breast cancer as they are the corner stone to identify the high risk groups who can benefit from adjuvant therapy and improving their disease prognosis. Aim of the study: in this study, we aimed to assess the value of serum omentin-1 levels as prognostic markers for breast cancer in Egyptian females. Patients and methods: 120 BC patients and 30 age and BMI matching health controls are the subjects of the study; we assessed the omentin-1 levels in the serum and correlated them with the clinicopathologic aspects in the BC patients. Results: our study showed that omentin-1 is significantly differing between healthy controls and BC patients, and revealed gradual increase with disease severity. Conclusion: our findings suggested that omentin-1 could be diagnostic marker for early cases detection and associated with breast cancer prognosis, supporting its role as prognostic biomarkers.

Role of Omentin-1 in the Diagnosis and Prognosis of Breast Cancer in Egyptian Females.