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This experiment aimed to evaluate the effect of different levels of Trigonella foenum graecum on liver structure and functions and some physiological and hematological parameters in normal male albino rats. A total of 24 male albino rats were used and divided into four groups (6 rats per group). The first group G1 was control group, G2 rats fed normal diet + 2.5% Trigonella foenum graecum, G3 rats fed normal diet +5% Trigonella foenum graecum and G4 rats fed normal diet +7.5% Trigonella foenum graecum. Blood samples were collected after 4 and 8 weeks from the start of the experiment. At the end of the experiment, rats were sacrificed to obtain the livers. Results indicated that Treatment of rats with 7.5% Trigonella Foenum graecum for 8 weeks significantly increased blood platelets. Treatment of rats with 2.5% Trigonella foenum graecum did not show any significant effect on liver function (activities of ALT and AST), serum total protein and albumin Meanwhile 5% or 7.5% Treigonella foenum graecum significantly increased ALT and AST activities. The results also showed that Treatment of rats with 5% or 7.5% Trigonella foenum graecum for 8 weeks caused mild ischemic changes of liver hepatocytes. It could be concluded that 2.5% Trigonella foenum graecum is safe to be used for 8 weeks without any adverse side effects on liver structure and function.

al-azhar journal of agricultural research

Effects of Trigonella foenum graecum L. seeds on liver structure, liver function biomarkers and some hematological and some physiological parameters in rats