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Background: Bacteria are resistant to an antibiotic such as Escherichia coli, Klebsiella pneumonia, and Enterobacter sp. responsible for morbidity in worldwide. ESβLs are a group of plasmids encoded enzymes that have the efficacy to hydrolyze β-lactams antibiotics. The spread of (ESβLs) representing a serious problem and threatening the ability to treat an infection. Aim of the study: This study aimed to investigate ESβLs-producing Enterobacteriaceae sp. isolated from patients and healthy individuals and detect the resistant genes blaTEM, blaSHV, and blaCTX-M. Patients and Methods: Two hundred bacterial isolates were recovered from patients and healthy individuals rectal swab samples. These isolates were screened for producing ESβLs and identified using both standard bacteriological methods and VITEK2 compact system). The antibiotics resistance of Enterobacteriaceae was assessed by the disk diffusion method and detection of blaTEM, blaSHV, and blaCTX-M genes by multiplex PCR. Results: Two hundred Enterobacteriaceae screening for-producing ESβLs showed that 56% (112/200) produce ESβLs. One hundred and twelve ESβLs-Enterobacteriaceae identified as following, Klebsiella pneumonia 51.73% (58/112), Escherichia coli and 46.40% (52/112), and Enterobacter cloacae 1.80% (2/112). The antibiotic resistance patterns of Enterobacteriaceae showed high resistance to ciprofloxacin, levofloxacin, and amikacin with the ratio of (71.76%), (60.72%) and (60.72%), respectively. Furthermore, ESβLs Enterobacteriaceae harbored genes blaCTX-M (78.6%), blaTEM (73.2%) and blaSHV (68.75%). The blaTEM was found the predominant gene in E. coli isolates 80.8%, while blaCTX-M in Klebsiella pneumonia 81%. Conclusion: The present study showed a significant distribution of multidrug-resistant ESβLs-producing Enterobacteriaceae in patients in the hospitaland community-acquired rectal infection. ESβLs-producing Enterobacteriaceae species harboring co-existence resistant genes.

al-azhar international medical journal /al-azhar international medical journal

Detection of blaTEM, blaSHV, and blaCTX-M genes among the Extended-Spectrum β-Lactamases (ESβLs) producing Enterobacteriaceae isolated from hospital-acquired infections and community in Egypt.