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HCV infection has an estimated prevalence of 3% around the world[1],and Egypt is among the highest prevalence [2]. Asymptomatic HCV patients are underrepresented.Unfortunately, many persons with HCV infection are asymptomatic[3]. Many asymptomatic seropositive donors have clinically significant liver disease[4]. The progression to severe fibrosis and occurrence of HCC were reported [1, 2]. Patients with normal enzymes may have definite chances of chronic hepatitis on histological examination [6].

Fibrogenesis Markers and Hepatic Histopathology : What is the Role?