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Distraction osteogenesis is defined as a procedure that can lengthen bone gradually. Complications may occur during this time, including refractors, local infections and loosening of the distractor device or pin. The most important disadvantage applies to the extended period of consolidation stage. Several methods were tested to improve new bone development, including the use of different adjuvant treatments; in order to minimize the time needed to complete the mandibular distraction osteogenesis MDO phases. Strontium is a medication used for treatment of osteoporosis and in osteoporotic patients; it has been shown that bone formation is promoted, while bone resorption is reduced. AIM OF THIS STUDY: This study aimed to assess the effects of strontium citrate during MDO in a rabbit model. MATERIALS AND METHODS: Fourteen rabbits weighing 3.0-3.5kg were separated into 2 groups: group I; (control group), group II; (received strontium citrate). Surgical procedures were performed to place the distractor system in both groups. The distractor was activated after 5 days of latency stage. After 4 weeks, all rabbits were euthanized and the distracted mandibles were surgically removed and prepared for light microscopic examination and histomorphometry. RESULTS: Comparing to the control group, histological results revealed thicker bone trabeculae in the study group with narrower bone marrow. The histomorphometric analysis also showed significantly higher percentage of new bone per field in the study group. CONCLUSIONS: Strontium citrate supplementation could enhance bone consolidation throughout the distraction osteogenesis.

EVALUATION OF THE EFFECT OF STRONTIUM CITRATE ON BONE CONSOLIDATION DURING MANDIBULAR DISTRACTION OSTEOGENESIS IN RABBITS (EXPERIMENTAL STUDY)