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As known, lipopolysaccharide (LPS) is a toxin that is secreted from gram negative bacteria as E. coli which is present in the gut of animals like sheep and it may be transported to the embryo through the blood affect the brain and other organs. Little is known about the effect of LPS on liver and kidney function or hematological parameters. In the present study we found that melatonin treatment improved most of the liver functions that affected by LPS injection and also improve kidney function, although LPS injection was found to lead to a decrease of createnine, urea and uric acid for unknown reason. concurrently injection of melatonin plus LPS led to decreasing most of blood indices while increasing of RBCs count and WBCs count. So, we concluded that usage of melatonin as general antioxidant is useful against LPS toxicity.

EFFECT OF LIPOPOLYSACCHARIDE AND THE AMELIORATIVE EFFECT OF THE ANTIOXIDANT MELATONIN ON SOME PHYSIOLOGICAL PARAMETERS OF SHEEP EMBRYOS