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The Magnetic Resonance Imaging (MRI) is a noninvasive technique based on the magnetic properties of the H atoms. Currently, about 30% of MRI exams use paramagnetic compounds, which are defined as contrast agents (CAs), able to reduce the relaxation times (T1 and T2) of hydrogen atoms from water molecules. In this review, we show the main compounds employed as CAs. Among these, Gd complexes are frequently used, but problems related to their high toxicity and relaxivities, promoting the development of new ACs, such as iron oxides, hybrid compounds as well as Mn and Ni complexes, which are less toxic and more

Contrast Agents for Magnetic Resonance Imaging: A Review