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Purpose: To compare pro re nata (PRN) and three scheduled loading injections of intravitreal bevacizumab for macular edema (ME) caused by branch retinal vein occlusion (BRVO). Methods: We retrospectively analyzed the medical records of 96 patients. We compared a group of patients who underwent treatment with intravitreal bevacizumab PRN with a second group that received three scheduled loading injections at 1 month intervals followed by PRN injections. Changes in visual acuity and central retinal thickness (CRT), and the need for additional injections over a 6 month period were compared. Results: The improvement in visual acuity and decrease in CRT were greater in the loading injection group, and the decreases in CRT at the 2, 3, and 6 months were statistically significant. The need for additional injections within 3 months after the last injection was significantly lower in the loading injection group. Conclusions: Over a 6 month period, the three loading injections seemed to be better than PRN injections for the treatment of ME in BRVO with regard to improvements in visual acuity and ME, reducing the need for additional injections within 3 months after the last injection.

Comparison of Pro Re Nata and Three Loading Injections of Intravitreal Bevacizumab for Macular Edema in Branch Retinal Vein Occlusion