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Since the emergence of H5N1 (A/goose/Guangdong/ 1/1996) in China in 1996, the viral HA has evolved into multiple distinct phylogenetic clades, subclades, and lineages around the globe. In 2014, the clade 2.3.4.4 H5Nx HPAIVs spread rapidly via migratory birds and evolved into four groups (A-D). A group C H5N6 outbreak was initially reported in Laos in 2013, then spread rapidly to Vietnam, Japan, South Korea, and China (26). In China, H5N6 viruses have widely circulated in wild waterfowl and poultry (1). A previous study showed that the H5N6 AIVs in poultry can transmit among ferrets via direct contact (23). H5N6 HPAIVs with the same genotype to human-origin strains have also been found in apparently healthy wild birds (2). So the virus can be transmitted through migratory birds, and almost all H5N6 patients have documented exposure to poultry and/or LPMs (1, 8). Therefore, surveillance for AIVs is needed in commercial poultry. Urumqi is located in the northern Tianshan Mountain, which is an important habitat for migratory A reassortant highly pathogenic avian influenza H5N6 virus originating from the wildbird-origin H5N6 and the poultry H9N2/H7N9 viruses in Xinjiang, China*)

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A reassortant highly pathogenic avian influenza H5N6 virus originating from the wildbird-origin H5N6 and the poultry H9N2/H7N9 viruses in Xinjiang, China