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Exocrine pancreas secretion is very important for digestion in the gut. This function is controlled by neuronal and hormonal pathways (4, 18). Gastric endocrine cells are a well-known source of many hormones, such as gastrin, ghrelin, obestatin, and nesfatin-1 (1, 33). These hormones take part in pancreas function, appetite control, energy regulation, and many physiological processes in the organism. Since the impact of these hormones on the body is multidirectional, procedures involving partial or total gastrectomy can have serious consequences for the physiological status and health of the organism. This should be taken into account in bariatric procedures aimed at body weight loss. As indicated by research, one of the consequences of gastrectomy may be changes in pancreatic exocrine function. Some authors report that gastrectomy results in cellular hyperplasia and hypertrophy, enzyme storage, and increased in vitro secretory capacity (6, 16). However, discrepancies are observed between humans and animals. The exocrine pancreatic insufficiency in humans after total gastrectomy contrasts with results from rat studies (11, 20). Moreover, true pancreatic functions in terms of enzyme activity are difficult to assess in humans. Most tests used for investigation of pancreas function are indirect. Removal of the acid-producing part of the stomach, gastric by-pass surgery, and gastrectomy resulted in decreased blood ghrelin levels (8, 10, 22). Ghrelin is found in oxyntic mucosa, as well as in the antrum and duodenum in moderate amounts (10). This hormone regulates the pituitary hormone axis, carbohydrate metabolism, and various functions of the heart, kidney, pancreas, adipose tissue, gonads, and cell proliferation (12). Data on nesfatin-1 response to gastric surgery are Effect of fundectomy, antrectomy and gastrectomy on pancreatic and brush border enzyme activity in rats