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Propofol, 2,6-diisopropylphenol, is a short-acting general anesthetic agent used in animals and humans. It is rapidly metabolized and is administrated intravenously with or without pre-anesthetics. It is also used in the induction of inhalation anesthesia (17, 30). It acts by stimulating gamma-aminobutyric acid (GABA) receptors and causes sedative, anesthetic, and analgesic effects (23, 28). It has a rapid recovery time and does not accumulate in tissues (18). A number of researchers have reported positive effects of propofol on muscular relaxation and minimum adverse effects on the cardiovascular and respiratory systems, but some other have reported a decreased ventilation rate and respiratory depth and apnea (9, 15). Metamizole, methane sulfonic acid sodium monohydrate or dipyrone, acts rapidly and has analgesic, muscle relaxant, anti-pyretic, and strong anti-inflammatory effects. Its mechanism of action is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) (24, 29). Some studies have shown that inappropriate doses of metamizole could possibly cause hypoxia, dyspnea, peripheral vasodilation, and hypothermia, while appropriate doses may not cause any disorders or renal or hepatic toxicity in the short term (10, 26). The side effects of metamizole on the cardiovascular system are not clear, and it has adequate compatibility with the respiratory and renal systems, blood serum, and blood glucose (2, 6). Benzodiazepines affect GABA receptors; they have a half-life of one hour in avian species and possess sedative, analgesic, and muscle relaxant effects. However, administration of high doses may induce cardiovascular and respiratory depression and may damage the renal tissue in the 1) This study is a part of a dissertation to be submitted by the first author to the Islamic Azad University, Science and Research Branch of Tehran, Iran. The study was supported by the Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University. Comparative study of midazolam-propofol and metamizole-propofol clinical effects in domestic pigeons1)