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Gamma/delta T lymphocytes (γδ T cells) in young ruminants account for at least 35-60% of the total lymphocytes in blood circulation (15). This unique feature of ruminants is beneficial from the research stand point because it allows acquisition of enough cells from just a few milliliters of blood without overtly stressing animals. Although γδ T cells are numerous in circulation, their role in immune response during infection is poorly understood. Moreover, the mechanisms involved in the activation of γδ T cells are not clear. It is for these reasons that bovine γδ T cells are of interest to veterinary immunologists as a research target. Bovine γδ T cells are separated into two main groups based on the expression of the WC1 molecule (4). WC1+ γδ T cells are reported to play an inflammatory role (14), while those expressing WC1.1+ are suggested to be regulatory, although other associations have been made by others (9, 11). Maślanka et al. (10) associate the suppressor profile of γδ T cells with expression of CD25, and WC1 with production of IFNγ, IL-10 and TGF-beta. WC1+ γδ T cells have been reported to have a role in innate immune responses, e.g., they are capable of IFNγ secretion and cytotoxicity against virus-infected cells, and are able to present antigen (18). Infection of bovine macrophages with Mycobacterium avium subspecies paratuberculosis can be modified by the presence of WC1+ γδ T cells (3). On the other hand, other infectious agents, such as low virulence or high virulence bovine viral diarrhoea virus, can induce depletion or redistribution of WC1+ γδ T cells upon infection, as reported by Palomares et al. (13). Knowledge about the nature of ligands recognized by γδ T cells is just as unclear (8), but it is likely to contribute to the rational design of vaccines against many infectious agents of Bovine gamma/delta T cells are stimulated by bovine coronavirus antigens identified by a soluble T cells receptor*)